Insulin activates single amiloride-blockable Na channels in a distal nephron cell line (A6).

@article{Marunaka1992InsulinAS,
  title={Insulin activates single amiloride-blockable Na channels in a distal nephron cell line (A6).},
  author={Yoshinori Marunaka and Nobutoshi Hagiwara and Hisako Tohda},
  journal={The American journal of physiology},
  year={1992},
  volume={263 3 Pt 2},
  pages={F392-400}
}
Using the patch-clamp technique, we studied the effect of insulin on an amiloride-blockable Na channel in the apical membrane of a distal nephron cell line (A6) cultured on permeable collagen films for 10-14 days. NPo (N, number of channels per patch membrane; Po, average value of open probability of individual channels in the patch) under baseline conditions was 0.88 +/- 0.12 (SE)(n = 17). After making cell-attached patches on the apical membrane which contained Na channels, insulin (1 mU/ml… CONTINUE READING

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