Insulin activates phospholipase C in fat cells: similarity with the activation of pyruvate dehydrogenase.

@article{KoepferHobelsberger1984InsulinAP,
  title={Insulin activates phospholipase C in fat cells: similarity with the activation of pyruvate dehydrogenase.},
  author={B Koepfer-Hobelsberger and O. H. Wieland},
  journal={Molecular and cellular endocrinology},
  year={1984},
  volume={36 1-2},
  pages={123-9}
}
Phospholipase C (PHL-C) activity determined in homogenates of fat cells treated with physiological concentrations of insulin showed a 2-3-fold increase as compared to controls in the absence of insulin. The changes of PHL-C and pyruvate dehydrogenase (PDH) activity which was measured concomitantly exhibited very similar characteristics as to insulin sensitivity, saturability, time dependence and glucose requirement. Exogenous PHL-C as an activator of PDH in fat cells (Honeyman et al., 1983… CONTINUE READING