Insulin Versus Glucagon Crosstalk: Central Plus Peripheral Mechanisms

@article{Lechin2013InsulinVG,
  title={Insulin Versus Glucagon Crosstalk: Central Plus Peripheral Mechanisms},
  author={F. Lechin and B. Dijs and B. Pardey-Maldonado},
  journal={American Journal of Therapeutics},
  year={2013},
  volume={20},
  pages={349–362}
}
Plasma glucose level depends on the peripheral intra-islet crosstalk between A cells (glucagon) + B-cells (insulin) and D-cells (somatostatin). Gastrointestinal hormones (secretin, CCK-PZ, gastrin, and serotonin) modulate the glucose- and amino acids–induced secretions of insulin and glucagon, respectively. Serotonin (5-HT) arose from the enterochromaffin cells during postprandial periods excites basal but inhibits excited B-cells. Serotonin excites adrenal glands that release adrenaline (Ad… Expand
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