Insulin Signaling and Heart Failure.

  title={Insulin Signaling and Heart Failure.},
  author={Christian Riehle and E. Dale Abel},
  journal={Circulation research},
  volume={118 7},
Heart failure is associated with generalized insulin resistance. Moreover, insulin-resistant states such as type 2 diabetes mellitus and obesity increases the risk of heart failure even after adjusting for traditional risk factors. Insulin resistance or type 2 diabetes mellitus alters the systemic and neurohumoral milieu, leading to changes in metabolism and signaling pathways in the heart that may contribute to myocardial dysfunction. In addition, changes in insulin signaling within… CONTINUE READING
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