Insulin Reverses D-Glucose–Increased Nitric Oxide and Reactive Oxygen Species Generation in Human Umbilical Vein Endothelial Cells

@inproceedings{Gonzlez2015InsulinRD,
  title={Insulin Reverses D-Glucose–Increased Nitric Oxide and Reactive Oxygen Species Generation in Human Umbilical Vein Endothelial Cells},
  author={M. Alcoberro Gonz{\'a}lez and Salom{\'e} Yurquina Rojas and P{\'i}a Avila and Lissette Cabrera and Roberto C. Oliveros Villalobos and Carlos Espino Palma and Claudio R Aguayo and Eduardo de la Pe{\~n}a and Victoria I Gallardo and Enrique Guzm{\'a}n-Gutierrez and T Estefan{\'i}a Saez and Roc{\'i}o Salsoso and Cristina Sanhueza and F. Mart{\'i}nez Pardo and Andrea Leiva and Luis Sobrevia},
  booktitle={PloS one},
  year={2015}
}
Vascular tone is controlled by the L-arginine/nitric oxide (NO) pathway, and NO bioavailability is strongly affected by hyperglycaemia-induced oxidative stress. Insulin leads to high expression and activity of human cationic amino acid transporter 1 (hCAT-1), NO synthesis and vasodilation; thus, a protective role of insulin on high D-glucose-alterations in endothelial function is likely. Vascular reactivity to U46619 (thromboxane A2 mimetic) and calcitonin gene related peptide (CGRP) was… CONTINUE READING

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