Insulin Resistance and Diabetes Increase Fibrosis in the Liver of Patients With Genotype 1 HCV Infection

@article{Petta2008InsulinRA,
  title={Insulin Resistance and Diabetes Increase Fibrosis in the Liver of Patients With Genotype 1 HCV Infection},
  author={Salvatore Petta and Calogero Camm{\`a} and Vito Di Marco and Nicola Alessi and Daniela Cabibi and Rosalia Caldarella and Anna Licata and Fatima Maria Massenti and Giuseppe Tarantino and Giulio Marchesini and Antonio Crax{\`i}},
  journal={The American Journal of Gastroenterology},
  year={2008},
  volume={103},
  pages={1136-1144}
}
OBJECTIVES:Metabolic factors may affect the course of chronic hepatitis C (CHC). Insulin resistance (IR) determines steatosis, but its direct role in affecting progression of hepatic fibrosis is less clear. We aimed to assess whether increasing degrees of IR, up to overt diabetes, are linked to steatosis and higher stages of fibrosis in patients with CHC resulting from genotype 1 HCV (G1-HCV).METHODS:Two hundred one consecutive patients with G1-HCV infection were evaluated by liver biopsy and… CONTINUE READING
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