Insulin Receptor Signaling in POMC, but Not AgRP, Neurons Controls Adipose Tissue Insulin Action

@inproceedings{Shin2017InsulinRS,
  title={Insulin Receptor Signaling in POMC, but Not AgRP, Neurons Controls Adipose Tissue Insulin Action},
  author={Andrew C. Shin and Nika Filatova and Claudia Lindtner and Tiffany Chi and Seta Degann and Douglas James Oberlin and Christoph Buettner},
  booktitle={Diabetes},
  year={2017}
}
Insulin is a key regulator of adipose tissue lipolysis, and impaired adipose tissue insulin action results in unrestrained lipolysis and lipotoxicity, which are hallmarks of the metabolic syndrome and diabetes. Insulin regulates adipose tissue metabolism through direct effects on adipocytes and through signaling in the central nervous system by dampening sympathetic outflow to the adipose tissue. Here we examined the role of insulin signaling in agouti-related protein (AgRP) and pro… CONTINUE READING
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