Insulin Protects Pancreatic Acinar Cells from Palmitoleic Acid-induced Cellular Injury*

@inproceedings{Samad2014InsulinPP,
  title={Insulin Protects Pancreatic Acinar Cells from Palmitoleic Acid-induced Cellular Injury*},
  author={Aysha Samad and Andrew D. James and James T. F. Wong and Parini Mankad and John Whitehouse and Waseema Patel and Marta Alves-Simoes and A K Siriwardena and Jason I. E. Bruce},
  booktitle={The Journal of biological chemistry},
  year={2014}
}
Acute pancreatitis is a serious and sometimes fatal inflammatory disease where the pancreas digests itself. The non-oxidative ethanol metabolites palmitoleic acid (POA) and POA-ethylester (POAEE) are reported to induce pancreatitis caused by impaired mitochondrial metabolism, cytosolic Ca(2+) ([Ca(2+)]i) overload and necrosis of pancreatic acinar cells. Metabolism and [Ca(2+)]i are linked critically by the ATP-driven plasma membrane Ca(2+)-ATPase (PMCA) important for maintaining low resting [Ca… CONTINUE READING
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