Insulin Promoter Factor 1 variation is associated with type 2 diabetes in African Americans


Defective insulin secretion is a key defect in the pathogenesis of type 2 diabetes (T2DM). The β-cell specific transcription factor, insulin promoter factor 1 gene (IPF1), is essential to pancreatic development and the maintenance of β-cell mass. We hypothesized that regulatory or coding variants in IPF1 contribute to defective insulin secretion and thus… (More)
DOI: 10.1186/1471-2350-6-37


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