Insulin-Like Growth Factor Binding Proteins: New Proteins, New Functions

@article{FerryJr1999InsulinLikeGF,
  title={Insulin-Like Growth Factor Binding Proteins: New Proteins, New Functions},
  author={Robert J. Ferry Jr. and Ruben W. Cerri and Pinchas Cohen},
  journal={Hormone Research in Paediatrics},
  year={1999},
  volume={51},
  pages={53 - 67}
}
The insulin-like growth factors (IGFs), IGF binding proteins (IGFBPs), and IGFBP proteases regulate somatic growth and cellular proliferation both in vivo and in vitro. IGFs are potent mitogens whose actions are determined by the availability of free IGFs to interact with IGF receptors. IGFBPs comprise a family of six proteins that bind IGFs with high affinity and specificity and thereby regulate IGF-dependent actions. IGFBPs have recently emerged as IGF-independent regulators of cell growth… 

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