Insulin-Like Growth Factor Binding Protein-3 Inhibits Colitis-Induced Carcinogenesis

  title={Insulin-Like Growth Factor Binding Protein-3 Inhibits Colitis-Induced Carcinogenesis},
  author={Avraham Belizon and Erdinç Balik and Irena Kirman and Helen Remotti and Nancy T Ciau and Suvinit Jain and R. Lawrence Whelan},
  journal={Diseases of the Colon & Rectum},
PurposeChronic inflammation in the setting of inflammatory bowel disease is thought to result in altered epithelial cell growth regulation and ultimately carcinogenesis. This loss in cell growth regulation may be partially caused by a decrease in circulating intact insulin-like growth factor binding protein-3 (IFGB-3) as a result of chronic inflammation. This study evaluates the effect of IFGB-3 on carcinogenesis in the setting of colitis.MethodsA previously described animal model for colitis… CONTINUE READING