Insulin-Like Growth Factor Axis and Risk of Type 2 Diabetes in Women

  title={Insulin-Like Growth Factor Axis and Risk of Type 2 Diabetes in Women},
  author={Swapnil N. Rajpathak and Meian He and Qi Sun and Robert C. Kaplan and Radhika Muzumdar and Thomas Rohan and Marc J. Gunter and Michael N. Pollak and Mimi Y. Kim and Jeffrey E. Pessin and Jeannette Michele Beasley and Judith Wylie-Rosett and Frank B Hu and Howard D. Strickler},
IGF-I shares structural homology and in vitro metabolic activity with insulin. Laboratory models suggest that IGF-I and its binding proteins IGFBP-1 and IGFBP-2 have potentially beneficial effects on diabetes risk, whereas IGFBP-3 may have adverse effects. We therefore conducted a prospective nested case-control investigation of incident diabetes (n = 742 case subjects matched 1:1 to control subjects) and its associations with IGF-axis protein levels in the Nurses' Health Study, a cohort of… CONTINUE READING
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