Insulin-Like Growth Factor 1 Receptor and Response to Anti-IGF1R Antibody Therapy in Osteosarcoma

@inproceedings{Cao2014InsulinLikeGF,
  title={Insulin-Like Growth Factor 1 Receptor and Response to Anti-IGF1R Antibody Therapy in Osteosarcoma},
  author={Yu Cao and Michael Roth and Sajida Piperdi and Kristofer Montoya and Rebecca Sowers and Pulivarthi H. Rao and David A. Geller and Peter J. Houghton and Edward A. Kolb and Jonathan B. Gill and Richard Gorlick},
  booktitle={PloS one},
  year={2014}
}
BACKGROUND Survival outcomes for patients with osteosarcoma (OS) have remained stagnant over the past three decades. Insulin-like growth factor 1 receptor (IGF1R) is over-expressed in a number of malignancies, and anti-IGF1R antibodies have and are currently being studied in clinical trials. Understanding the molecular aberrations which result in increased tumor response to anti-IGF1R therapy could allow for the selection of patients most likely to benefit from IGF1R targeted therapy. METHODS… CONTINUE READING

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