Insulin Knockout Mice Have Extended Survival but Volatile Blood Glucose Levels on Leptin Therapy.

@article{Neumann2016InsulinKM,
  title={Insulin Knockout Mice Have Extended Survival but Volatile Blood Glucose Levels on Leptin Therapy.},
  author={Ursula Neumann and Heather C. Denroche and Majid Mojibian and Scott D. Covey and Timothy J Kieffer},
  journal={Endocrinology},
  year={2016},
  volume={157 3},
  pages={
          1007-12
        }
}
Leptin can reverse hyperglycemia in rodent models of type 1 diabetes. However, these models have used chemical or immune mediated β-cell destruction where insulin depletion is incomplete. Thus it is unknown which actions of leptin are entirely insulin independent, versus those which require insulin. To directly assess this we maximized blockage of insulin action using an insulin receptor antagonist in combination with streptozotocin-diabetic mice; leptin treatment was still able to reduce blood… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 2 times. VIEW TWEETS