Insulin Infusion During Normoglycemia Modulates Insulin Secretion According to Whole-Body Insulin Sensitivity

@inproceedings{Anderwald2011InsulinID,
  title={Insulin Infusion During Normoglycemia Modulates Insulin Secretion According to Whole-Body Insulin Sensitivity},
  author={Christian Heinz Anderwald and Andrea Tura and Angela Grassi and Michael R Krebs and Julia Szendroedi and Michael Roden and Martin Georg Bischof and Anton Luger and Giovanni Pacini},
  booktitle={Diabetes care},
  year={2011}
}
OBJECTIVE Glucose is the major stimulus for insulin release. Time course and amount of insulin secreted after glycemic stimulus are different between type 2 diabetes mellitus (T2DM) patients and healthy subjects. In rodents, it was demonstrated that insulin can modulate its own release. Previous studies in humans yielded contrasting results: Insulin was shown to have an enhancing effect, no effect, or a suppressive effect on its own secretion. Thus, we aimed to evaluate short-term effects of… CONTINUE READING
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