Insulin Glargine

@article{McKeage2012InsulinG,
  title={Insulin Glargine},
  author={K. McKeage and K. Goa},
  journal={Drugs},
  year={2012},
  volume={61},
  pages={1599-1624}
}
  • K. McKeage, K. Goa
  • Published 2012
  • Medicine
  • Drugs
  • SummaryAbstractInsulin glargine is a recombinant human insulin analogue produced by DNA technology using a nonpathogenic strain of Escherichia coli. Two modifications of human insulin result in a stable molecule which is soluble in slightly acidic conditions (pH 4.0) and precipitates in the neutral pH of subcutaneous tissue. Because of these properties, absorption of insulin glargine is delayed and the analogue provides a fairly constant, basal insulin supply without peaks in plasma insulin… CONTINUE READING
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