Insulin-FOXO3 Signaling Modulates Circadian Rhythms via Regulation of Clock Transcription

@article{Chaves2014InsulinFOXO3SM,
  title={Insulin-FOXO3 Signaling Modulates Circadian Rhythms via Regulation of Clock Transcription},
  author={In{\^e}s Chaves and Gijsbertus T.J. van der Horst and Raymond D. Schellevis and Romana M. Nijman and Marian J. A. Groot Koerkamp and Frank Holstege and Marten P Smidt and Marco F. M. Hoekman},
  journal={Current Biology},
  year={2014},
  volume={24},
  pages={1248-1255}
}
Circadian rhythms are responsive to external and internal cues, light and metabolism being among the most important. In mammals, the light signal is sensed by the retina and transmitted to the suprachiasmatic nucleus (SCN) master clock [1], where it is integrated into the molecular oscillator via regulation of clock gene transcription. The SCN synchronizes… CONTINUE READING