Insulin-Dependent Diabetes Mellitus

@article{Tisch1996InsulinDependentDM,
  title={Insulin-Dependent Diabetes Mellitus},
  author={Roland Michael Tisch and Hugh O. Mcdevitt},
  journal={Cell},
  year={1996},
  volume={85},
  pages={291-297}
}
Early attempts to prevent IDDM typically relied on immunosuppressive drugs (cyclosporine) or drugs that indiscriminantly inhibit cell proliferation (imuran), often leading to serious side effects. Therefore, a great deal of effort has focused on selectively targeting those T cells involved in the disease process. One general approach has been to employ monoclonal antibodies specific for molecules expressed by the effector T cell population. Monoclonal antibodies specific for CD4 (Shizuru et al… CONTINUE READING

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