Insulin Action in Brain Regulates Systemic Metabolism and Brain Function

@inproceedings{Kleinridders2014InsulinAI,
  title={Insulin Action in Brain Regulates Systemic Metabolism and Brain Function},
  author={Andr{\'e} Kleinridders and Heather A. Ferris and Weikang Cai and C Ronald Kahn},
  booktitle={Diabetes},
  year={2014}
}
Insulin receptors, as well as IGF-1 receptors and their postreceptor signaling partners, are distributed throughout the brain. Insulin acts on these receptors to modulate peripheral metabolism, including regulation of appetite, reproductive function, body temperature, white fat mass, hepatic glucose output, and response to hypoglycemia. Insulin signaling also modulates neurotransmitter channel activity, brain cholesterol synthesis, and mitochondrial function. Disruption of insulin action in the… CONTINUE READING
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