Insulin's impact on renal sodium transport and blood pressure in health, obesity, and diabetes.

  title={Insulin's impact on renal sodium transport and blood pressure in health, obesity, and diabetes.},
  author={Swasti Tiwari and Shahla Riazi and Carolyn A. Ecelbarger},
  journal={American journal of physiology. Renal physiology},
  volume={293 4},
Insulin has been shown to have antinatriuretic actions in humans and animal models. Moreover, endogenous hyperinsulinemia and insulin infusion have been correlated to increased blood pressure in some models. In this review, we present the current state of understanding with regard to the regulation of the major renal sodium transporters by insulin in the kidney. Several groups, using primarily cell culture, have demonstrated that insulin can directly increase activity of the epithelial sodium… 

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