Insulin‐like growth factor‐binding protein‐2 in patients with prostate carcinoma and benign prostatic hyperplasia

@article{Ho1997InsulinlikeGF,
  title={Insulin‐like growth factor‐binding protein‐2 in patients with prostate carcinoma and benign prostatic hyperplasia},
  author={Phy Ho and Robert C. Baxter},
  journal={Clinical Endocrinology},
  year={1997},
  volume={46}
}
  • P. Ho, R. Baxter
  • Published 1 February 1997
  • Medicine, Biology
  • Clinical Endocrinology
OBJECTIVE Insulin‐like growth factor‐binding protein (IGFBP)‐2 is a major prostatic IGFBP and may be involved in regulating prostate growth. Patients with prostate carcinoma (PC) have elevated serum IGFBP‐2 levels which correlate with the specific PC marker, prostate‐specific antigen (PSA). The aims of this study were to investigate whether elevated serum IGFBP‐2 is unique to PC or also occurs in benign prostatic hyperplasia (BPH), to examine the relations among age, PSA and IGFBP‐2 levels, and… 
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TLDR
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TLDR
In addition to AFP, IGFBP-2 appears to be a suitable marker for the evaluation of the serological status of HCC patients, as is the case when nutrition, hepatic function and growth hormone (GH) secretion are decreased.
High expression of insulin‐like growth factor binding protein–2 messenger RNA in epithelial ovarian cancers produces elevated preoperative serum levels
  • J. Lancaster, R. Sayer, A. Berchuck
  • Biology, Medicine
    International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • 2006
TLDR
The findings provide further support that the insulin-like growth factor pathway plays a significant role in epithelial ovarian cancer pathogenesis and that IGFBP-2 may represent an additional serum biomarker with utility in detection and monitoring of epithel ovarian cancer.
Elevated Serum Insulin-Like Growth Factor Binding Protein-2 as a Prognostic Marker in Patients with Ovarian Cancer
TLDR
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