Insulin/insulin-like growth factor I hybrid receptors overexpression is not an early defect in insulin-resistant subjects.

@article{Spampinato2000InsulininsulinlikeGF,
  title={Insulin/insulin-like growth factor I hybrid receptors overexpression is not an early defect in insulin-resistant subjects.},
  author={Daniela Spampinato and G Pandini and Antonio Iuppa and Vincenzo Trischitta and Riccardo Vigneri and Lucia Frittitta},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2000},
  volume={85 11},
  pages={4219-23}
}
Hybrid receptors (HRs), insulin receptor (IR)/insulin-like growth factor I receptor (IGF-I-R) heterodimers have been reported increased in skeletal muscle of obese and type 2 diabetic patients and to contribute to the patient insulin resistance. To investigate whether or not the increased expression of hybrid receptors is an early defect (probably genetic… CONTINUE READING