Insulin/glucose induces natriuretic peptide clearance receptor in human adipocytes: a metabolic link with the cardiac natriuretic pathway.

@article{Bordicchia2016InsulinglucoseIN,
  title={Insulin/glucose induces natriuretic peptide clearance receptor in human adipocytes: a metabolic link with the cardiac natriuretic pathway.},
  author={Marica Bordicchia and M Ceresiani and Marco Pavani and Daniele Minardi and Marella Polito and Martin Wabitsch and Valentina Cannone and John C. Burnett and Paolo Dess{\`i}-Fulgheri and Riccardo Sarzani},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2016},
  volume={311 1},
  pages={R104-14}
}
Cardiac natriuretic peptides (NP) are involved in cardiorenal regulation and in lipolysis. The NP activity is largely dependent on the ratio between the signaling receptor NPRA and the clearance receptor NPRC. Lipolysis increases when NPRC is reduced by starving or very-low-calorie diet. On the contrary, insulin is an antilipolytic hormone that increases sodium retention, suggesting a possible functional link with NP. We examined the insulin-mediated regulation of NP receptors in differentiated… CONTINUE READING
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