Insulin/Insulin-like growth factor signaling controls non-Dauer developmental speed in the nematode Caenorhabditis elegans.

@article{Ruaud2011InsulinInsulinlikeGF,
  title={Insulin/Insulin-like growth factor signaling controls non-Dauer developmental speed in the nematode Caenorhabditis elegans.},
  author={Anne-Françoise Ruaud and Iskra Katic and J L Bessereau},
  journal={Genetics},
  year={2011},
  volume={187 1},
  pages={337-43}
}
Identified as a major pathway controlling entry in the facultative dauer diapause stage, the DAF-2/Insulin receptor (InsR) signaling acts in multiple developmental and physiological regulation events in Caenorhabditis elegans. Here we identified a role of the insulin-like pathway in controlling developmental speed during the C. elegans second larval stage. This role relies on the canonical DAF-16/FOXO-dependent branch of the insulin-like signaling and is largely independent of dauer formation… CONTINUE READING
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