Insulin/IGF-like signalling, the central nervous system and aging.

  title={Insulin/IGF-like signalling, the central nervous system and aging.},
  author={Susan Jane Broughton and Linda Partridge},
  journal={The Biochemical journal},
  volume={418 1},
Enormous strides in understanding aging have come from the discovery that mutations in single genes can extend healthy life-span in laboratory model organisms such as the yeast Saccharomyces, the fruit fly Drosophila melanogaster, the nematode worm Caenorhabditis elegans and the mouse. IIS [insulin/IGF (insulin-like growth factor)-like signalling] stands out as an important, evolutionarily conserved pathway involved in the determination of lifespan. The pathway has diverse functions in… CONTINUE READING
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