Insulin/Foxo1 pathway regulates expression levels of adiponectin receptors and adiponectin sensitivity.

  title={Insulin/Foxo1 pathway regulates expression levels of adiponectin receptors and adiponectin sensitivity.},
  author={Atsushi Tsuchida and Toshimasa Yamauchi and Yusuke Ito and Yusuke Hada and Toshiyuki Maki and Sato Takekawa and Junji Kamon and Masaki Kobayashi and Ryo Suzuki and Kazuo Hara and Naoto Kubota and Yasuo Terauchi and Philippe Froguel and Jun Nakae and Masato Kasuga and Domenico Accili and Kazuyuki Tobe and Kohjiro Ueki and Ryozo Nagai and Takashi Kadowaki},
  journal={The Journal of biological chemistry},
  volume={279 29},
Adiponectin/Acrp30 is a hormone secreted by adipocytes, which acts as an antidiabetic and antiatherogenic adipokine. We reported previously that AdipoR1 and -R2 serve as receptors for adiponectin and mediate increased fatty acid oxidation and glucose uptake by adiponectin. In the present study, we examined the expression levels and roles of AdipoR1/R2 in several physiological and pathophysiological states such as fasting/refeeding, obesity, and insulin resistance. Here we show that the… CONTINUE READING
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