Insulin, not leptin, promotes in vitro cell migration to heal monolayer wounds in human corneal epithelium.

@article{Shanley2004InsulinNL,
  title={Insulin, not leptin, promotes in vitro cell migration to heal monolayer wounds in human corneal epithelium.},
  author={Lynne J. Shanley and Colin D. McCaig and John V. Forrester and Min Zhao},
  journal={Investigative ophthalmology & visual science},
  year={2004},
  volume={45 4},
  pages={1088-94}
}
PURPOSE To investigate the effects of insulin and leptin on in vitro wound healing of transformed human corneal epithelial cell monolayers and to identify cellular (migration versus proliferation) and intracellular signaling mechanisms. METHODS Scratch wounds were created in monolayers of an immortalized human corneal epithelial cell (HCEC) line. The wounded monolayers were exposed to insulin and leptin. Wound areas were measured every hour after wounding for up to 8 hours. Phosphoinositide 3… CONTINUE READING

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