Insulin, insulin-like growth factor-I (IGF-I), IGF binding proteins, their biologic interactions, and colorectal cancer.

@article{Sandhu2002InsulinIG,
  title={Insulin, insulin-like growth factor-I (IGF-I), IGF binding proteins, their biologic interactions, and colorectal cancer.},
  author={Manjinder S. Sandhu and David B Dunger and Edward L. Giovannucci},
  journal={Journal of the National Cancer Institute},
  year={2002},
  volume={94 13},
  pages={972-80}
}
Secular changes and worldwide variations in incidence rates of colorectal cancer, along with results from twin and migrant studies, provide compelling evidence that environmental factors influence the risk of this disease. Among the most important of these factors are diet and associated factors, such as physical activity and body size. Recent data suggest that dietary and related factors may influence colorectal cancer risk via their effects on serum insulin concentrations and on the… CONTINUE READING
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