Insulin, insulin-like growth factor-I, and risk of breast cancer in postmenopausal women.

  title={Insulin, insulin-like growth factor-I, and risk of breast cancer in postmenopausal women.},
  author={Marc J. Gunter and Donald R Hoover and Herbert Yu and Sylvia Wassertheil-Smoller and Thomas Rohan and Joann E. Manson and Jixin Li and Gloria Y. F. Ho and Xiaonan Xue and Garnet L. Anderson and Robert C. Kaplan and T. G. Harris and Barbara V Howard and Judith Wylie-Rosett and Robert D Burk and Howard D. Strickler},
  journal={Journal of the National Cancer Institute},
  volume={101 1},
BACKGROUND The positive association between obesity and postmenopausal breast cancer has been attributed, in part, to the fact that estrogen, a risk factor for breast cancer, is synthesized in adipose tissue. Obesity is also associated with high levels of insulin, a known mitogen. However, no prospective studies have directly assessed associations between circulating levels of insulin and/or insulin-like growth factor (IGF)-I, a related hormone, and the risk of breast cancer independent of… CONTINUE READING
Highly Influential
This paper has highly influenced 10 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Recent Discussions
This paper has been referenced on Twitter 9 times over the past 90 days. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 218 extracted citations


Publications referenced by this paper.
Showing 1-10 of 60 references

Similar Papers

Loading similar papers…