Insulin, insulin-like growth factor-I, and platelet-derived growth factor activate extracellular signal-regulated kinase by distinct pathways in muscle cells.

@article{Tsakiridis2001InsulinIG,
  title={Insulin, insulin-like growth factor-I, and platelet-derived growth factor activate extracellular signal-regulated kinase by distinct pathways in muscle cells.},
  author={Theodoros K Tsakiridis and Evangelia Tsiani and Poli Lekas and A. Bergman and Vera Cherepanov and Catharine Whiteside and Gregory P Downey},
  journal={Biochemical and biophysical research communications},
  year={2001},
  volume={288 1},
  pages={205-11}
}
We have investigated the signaling pathways initiated by insulin, insulin-like growth factor-1 (IGF-I), and platelet-derived growth factor (PDGF) leading to activation of the extracellular signal-regulated kinase (ERK) in L6 myotubes. Insulin but not IGF-I or PDGF-induced ERK activation was abrogated by Ras inhibition, either by treatment with the farnesyl transferase inhibitor FTP III, or by actin disassembly by cytochalasin D, previously shown to inhibit Ras activation. The protein kinase C… CONTINUE READING

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