Insulators and domains of gene expression.

  title={Insulators and domains of gene expression.},
  author={Tamer Ali and Rainer Renkawitz and Marek Bartkuhn},
  journal={Current opinion in genetics & development},
The genomic organization into active and inactive chromatin domains imposes specific requirements for having domain boundaries to prohibit interference between the opposing activities of neighbouring domains. These boundaries provide an insulator function by binding architectural proteins that mediate long-range interactions. Among these, CTCF plays a prominent role in establishing chromatin loops (between pairs of CTCF binding sites) through recruiting cohesin. CTCF-mediated long-range… CONTINUE READING
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