Insulators: linking genome architecture to gene regulation

  title={Insulators: linking genome architecture to gene regulation},
  author={Robert White},
  booktitle={F1000 biology reports},
Insulator elements have long been associated with a proposed domain boundary function, ensuring appropriate associations between regulatory elements and transcription units through the physical organisation of the genome into looped domains. Recent experiments in Drosophila have, however, highlighted a more direct involvement of insulators in transcriptional regulation.