Insular Cortex Lesions Impair the Acquisition of Conditioned Immunosuppression

@article{RamirezAmaya1996InsularCL,
  title={Insular Cortex Lesions Impair the Acquisition of Conditioned Immunosuppression},
  author={Victor Ramirez-Amaya and Benjam{\'i}n Alvarez-Borda and Christopher E. Ormsby and Rub{\'e}n D. Martı́nez and Ruy P{\'e}rez-Montfort and Federico Berm{\'u}dez-Rattoni},
  journal={Brain, Behavior, and Immunity},
  year={1996},
  volume={10},
  pages={103-114}
}
Conditioned immunosuppression can be readily obtained in animals by associating a taste with an immunosuppressive drug. On subsequent exposure to the conditioned taste, the animals show an attenuated immune response and also exhibit a conditioned taste aversion. It has been established that insular cortex lesions disrupt the acquisition of conditioned taste aversion. The effect of NMDA-induced lesions in either the insular cortex or the parietal cortex of male Wistar rats was evaluated in the… Expand
Differential Effects of NMDA-Induced Lesions into the Insular Cortex and Amygdala on the Acquisition and Evocation of Conditioned Immunosuppression
TLDR
The results of this work suggest that the IC is involved in the neural mechanisms underlying the acquisition and evocation of conditioned immunosuppression, and the amygdala could be important in mediating the input of the immune information necessary for the acquisition of conditioned immunity. Expand
Neural Substrates for Behaviorally Conditioned Immunosuppression in the Rat
TLDR
The present data reveal relevant neural mechanisms underlying the learning and memory processes of behaviorally conditioned immunosuppression. Expand
Conditioned Enhancement of Antibody Production Is Disrupted by Insular Cortex and Amygdala but Not Hippocampal Lesions
TLDR
Evidence that an excitotoxic lesion bilaterally applied into the insular cortex or the amygdala, but not into the dorsal hippocampus, impaired the acquisition of both odor and gustatory conditioned immune enhancement is shown, suggesting that the amygdala and theinsular cortex are involved in the neural-immune interactions that mediate conditioned immunity. Expand
Enhancement of antibody production and expression of c-Fos in the insular cortex in response to a conditioned stimulus after a single-trial learning paradigm
TLDR
The re-exposure of conditioned rats to the conditioned stimulus resulted in a significant increase of c-Fos immunoreactivity in all three areas of the IC including the agranular, dysgranular, and granular areas, suggesting that IC is involved in the neural mechanism of expression of conditioned immune response. Expand
Murine taste-immune associative learning
TLDR
The present results indicate that mice seem to be capable of associating a gustative stimulus with CsA, resulting in behaviorally conditioned immunosuppression without affecting appetitive behavior. Expand
Gustatory insular cortex lesions disrupt drug-induced, but not lithium chloride-induced, suppression of conditioned stimulus intake.
TLDR
The current data show that the insular taste cortex plays an integral role in drug-induced avoidance of a gustatory CS, and is overridden by a 20 mg/kg dose of the drug. Expand
Short communication Murine taste-immune associative learning
TLDR
The present results indicate that mice seem to be capable of associating a gustative stimulus with CsA, resulting in behaviorally conditioned immunosuppression without aVecting appetitive behavior. Expand
Behavioural endocrine immune-conditioned response is induced by taste and superantigen pairing
TLDR
Re-exposure to the conditioned stimulus significantly increased IL-2, interferon-gamma and corticosterone plasma levels, in comparison with conditioned animals which had not been re-exposed to saccharin taste, demonstrating a behavioural-immune-endocrine conditioned response using a superantigen as unconditioned stimulus. Expand
PAVLOVIAN CONDITIONING OF IMMUNOLOGICAL AND NEUROENDOCRINE FUNCTIONS.
TLDR
Increased knowledge about the neuropsychological machinery steering learning and memory processes together with recent insight into the mechanisms mediating placebo responses provides fascinating perspectives to exploit these learned immune and neuroendocrine responses as supportive therapies, the aim being to reduce the amount of medication required, diminishing unwanted drug side effects while maximizing the therapeutic effect for the patient's benefit. Expand
Taste Aversion Learning as a Tool for the Study of Hippocampal and Non-Hippocampal Brain Memory Circuits Regulating Diet Selection.
TLDR
Taste aversion learning is proposed as a useful behavioral tool in the investigation of different brain circuits that are critical for food selection by the study of interactions between hippocampal and non-hippocampal dependent memory systems. Expand
...
1
2
3
4
...

References

SHOWING 1-10 OF 34 REFERENCES
Behaviorally Conditioned Immunosuppression
An illness-induced taste aversion was conditioned in rats by pairing saccharin with cyclophosphamide, an immunosuppressive agent. Three days after conditioning, all animals were injected with sheepExpand
Differential involvement of gustatory insular cortex and amygdala in the acquisition and retrieval of conditioned taste aversion in rats
TLDR
It is argued that GC and Am implement processing of gustatory and visceral signals, respectively, but that formation and consolidation of the CTA engram proceeds outside forebrain, probably at the level of the brainstem. Expand
Lesions of the hippocampus enhance or depress humoral immunity in rats.
TLDR
The results suggest that different areas of the hippocampus can stimulate or inhibit humoral immunity, and chemical destruction of pyramidal cell bodies in CA2 and CA3 significantly increased humoral immune as measured by HC50, but larger chemical lesions that also included CA1 did not. Expand
Brain neocortex immunomodulation in rats
TLDR
The results suggest that lateralization in brain cortex immunomodulatory functions may exist in both sexes and in several species of mammals. Expand
Place and taste aversion learning: Role of basal forebrain, parietal cortex, and amygdala
TLDR
The findings suggest parallel functions for the NBM component of the basal forebrain system and the parietal cortex in mediating memory appears to be limited in that it does not play a role in all learning situations. Expand
CNS–immune system interactions: Conditioning phenomena.
TLDR
Recent studies documenting behaviorally conditioned suppression and enhancement of immunity appear to show that the immune system is integrated with other psychophysiological processes and subject to modulation by the brain. Expand
Conditioned suppression of humoral immunity in the rat.
TLDR
Conconditioned animals reexposed to the CS had lower antibody titers than placebo-treated animals 4, 6, and 8 days after antigenic stimulation, suggesting that reexposure to a CS may have long-lasting effects. Expand
Dopamine D1 Receptors in the Amygdala Enhance the Immune Response in the Rat a
TLDR
Results indicate that activation of dopamine D1 receptors within the central amygdala induced selective stimulation of mitogen responsiveness of splenocytes and suggest that specificactivation of dopamine neurotransmission within selected areas of the limbic system may produce immunoenhancing effects, which further confirm the immunomodulatory role played by dopaminergic mechanisms in the brain. Expand
Asymmetrical brain modulation of the immune response
  • P. Neveu
  • Medicine, Psychology
  • Brain Research Reviews
  • 1992
TLDR
The experimental models for investigating asymmetrical brain modulation of the immune system may be useful for studying physiological, pathological and genetic aspects of neuroimmunomodulation. Expand
Cortical substrates of taste aversion learning: Direct amygdalocortical projections to the gustatory neocortex do not mediate conditioned taste aversion learning
The gustatory neocortex (GN) receives direct projections from the lateral and basolateral amygdaloid nuclei. Amygdalocortical afferents ascend to the GN via the external capsule and the claustrum.Expand
...
1
2
3
4
...