Insula reactivity and connectivity to anterior cingulate cortex when processing threat in generalized social anxiety disorder.

@article{Klumpp2012InsulaRA,
  title={Insula reactivity and connectivity to anterior cingulate cortex when processing threat in generalized social anxiety disorder.},
  author={Heide Klumpp and Michael Angstadt and K. Luan Phan},
  journal={Biological psychology},
  year={2012},
  volume={89 1},
  pages={273-6}
}
Aberrant subcortical-prefrontal connectivity may contribute to insula hyper-reactivity to threat in generalized social anxiety disorder (gSAD). A novel PsychoPhysiological Interaction (PPI) analysis was used to examine functional 'coupling' between the insula and prefrontal cortex in gSAD patients and healthy controls (HCs). During fMRI, 29 gSAD and 26 HC volunteers performed an Emotional Face Matching Task, involving the processing of fear, angry, and happy expressions. As expected, compared… CONTINUE READING
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