Insula Damage and Quitting Smoking

@article{Vorel2007InsulaDA,
  title={Insula Damage and Quitting Smoking},
  author={Stanislav R. Vorel and Adam Bisaga and Guy Mckhann and Herbert D. Kleber},
  journal={Science},
  year={2007},
  volume={317},
  pages={318 - 319}
}
In their Report “Damage to the insula disrupts addiction to cigarette smoking” (26 Jan., p. [531][1]), which is based on a retrospective study of patients who had brain lesions, N. H. Naqvi et al. conclude that damage to the insula was responsible for the disruption of nicotine dependence in 
The insula and drug addiction: an interoceptive view of pleasure, urges, and decision-making
TLDR
A novel theoretical framework for addiction is proposed in which the insula represents the interoceptive effects of drug taking, making this information available to conscious awareness, memory and executive functions. Expand
The insula: a critical neural substrate for craving and drug seeking under conflict and risk
TLDR
In this framework, the insula functions in the recall of interoceptive drug effects during craving and drug seeking under specific conditions where drug taking is perceived as risky and/or where there is conflict between drug taking and more adaptive goals. Expand
Examining the role of the insular cortex in addiction-relevant behaviours
INTRODUCTION: Recently recognized as a critical brain region underlying the neurocircuitry of addiction, the body of evidence supporting the role of the insular cortex across multiple aspects ofExpand
Inhibitory control and emotional stress regulation: Neuroimaging evidence for frontal–limbic dysfunction in psycho-stimulant addiction
  • C. Li, R. Sinha
  • Medicine, Psychology
  • Neuroscience & Biobehavioral Reviews
  • 2008
TLDR
The overarching thesis is that prefrontal activity ensures intact emotional stress regulation and inhibitory control and will likely provide the key to understanding the mechanisms underlying compulsive drug use behaviors in psycho-stimulant dependence. Expand
Translational strategies for therapeutic development in nicotine addiction: Rethinking the conventional bench to bedside approach
TLDR
Pre-clinical models of addiction are used to explore the role of insula in addiction and the possibility of close interaction between both models seems to be critical for the successful development of novel therapeutic strategies for nicotine dependence. Expand
HIV-Tat Protein mediation of NeuroAIDS central nervous system pathology and behavioral deficits
OF DISSERTATION Submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Psychology in the Graduate School of Arts and Sciences of Northeastern University, June,Expand
Reward and adversity processing circuits, their competition and interactions with dopamine and serotonin signaling
TLDR
D dopamine attenuates the output of the adversity processing circuit, thus decreasing inhibitory avoidance and self-control, while serotonin attenuates dACC, AI, clOFC, D1 loop of VS, LHb, amygdala and pain pathway. Expand
What does addiction medicine expect from neuroscience? From genes and neurons to treatment responses.
The field of neuroscience is rapidly growing as evidenced by the mapping of the human genome, the progress in brain imaging technologies, and the refinement of sophisticated molecular tools that canExpand
What does addiction medicine expect from neuroscience? From genes and neurons to treatment responses.
TLDR
The potential of neuroscience to address some of the pressing questions in Addiction Medicine is illustrated, using recent research developments, to illustrate the clinical and research needs in addiction medicine. Expand
Nicotine Addiction: Mechanisms and Consequences
TLDR
This work aims to provide a systematic review and meta-analysis of the literature on canine coronavirus infection and its role in the pathophysiology of schizophrenia and its treatment by emphasizing the importance of cleanliness and minimizing the number of infections. Expand
...
1
2
...

References

SHOWING 1-10 OF 14 REFERENCES
Anhedonia after a selective bilateral lesion of the globus pallidus.
TLDR
Comprehensive neuropsychological tests revealed intact cognitive functions, including attention, working memory, and executive function, and an indicated absence of a frontal-subcortical syndrome in a 34-year-old man who came to the authors' outpatient clinic for treatment of a major depressive episode. Expand
Brain metabolic changes during cigarette craving.
TLDR
Brain regions associated with arousal, compulsive repetitive behaviors, sensory integration, and episodic memory are activated during exposure to cigarette-related cues and cigarette craving, similar to findings with other addictive substances. Expand
Neuropsychiatric effects of insular stroke.
TLDR
Subjective feelings of impaired energy or drive after right insular damage may result from disconnection between the insula and the frontal lobe or the anterior cingulate cortex, structures that have been associated with willed action and motor behavior. Expand
The role of insula in language: an unsettled question
In this paper some of Benson's ideas about the role of the insula in language are developed. It is proposed that the insula is involved in two di erent aspects of language. On one hand, the insulaExpand
Neural Systems and Cue-Induced Cocaine Craving
TLDR
The results suggest that induction of drug craving involves a neural network that assigns incentive motivational value to environmental stimuli through the coactivation of brain regions that process information about memories and emotions. Expand
Regional brain metabolic activation during craving elicited by recall of previous drug experiences.
TLDR
Activation of the temporal insula, a brain region involved with autonomic control, and of the orbitofrontal cortex, abrain region involvedWith expectancy and reinforcing salience of stimuli, during the cocaine theme support their involvement with craving in cocaine addicted subjects. Expand
Neglect after right insular cortex infarction.
TLDR
The right insular cortex seems to have a role in awareness of external stimuli, and infarction in this area may lead to neglect in multisensory modalities. Expand
Stereotactic neurosurgical treatment of addiction: minimizing the chances of another 'great and desperate cure'.
TLDR
The addictions field will need to speak with a united voice to ensure that neurosurgical treatment of addiction is not introduced into developed countries by enthusiastic private practitioners without formal evaluation, as purported 'cures' for heroin addiction all too often are. Expand
Neuroanatomic correlates of stroke-related myocardial injury
TLDR
Brain regions that were a priori associated with cTnT elevation included the right posterior, superior, and medial insula and the right inferior parietal lobule, indicative of myocardial injury. Expand
Medication screening for smoking cessation: a proposal for new methodologies
TLDR
The clinical validity of short-term screening studies may improve if these studies simulate some clinical trial procedures within practical limitations, and other research aimed specifically at identifying the mechanisms of therapeutic action of a medication may also profit from using this approach. Expand
...
1
2
...