Insula Damage and Quitting Smoking

  title={Insula Damage and Quitting Smoking},
  author={Stanislav R. Vorel and Adam Bisaga and Guy Mckhann and Herbert D. Kleber},
  pages={318 - 319}
In their Report “Damage to the insula disrupts addiction to cigarette smoking” (26 Jan., p. [531][1]), which is based on a retrospective study of patients who had brain lesions, N. H. Naqvi et al. conclude that damage to the insula was responsible for the disruption of nicotine dependence in 

The insula and drug addiction: an interoceptive view of pleasure, urges, and decision-making

A novel theoretical framework for addiction is proposed in which the insula represents the interoceptive effects of drug taking, making this information available to conscious awareness, memory and executive functions.

The insula: a critical neural substrate for craving and drug seeking under conflict and risk

In this framework, the insula functions in the recall of interoceptive drug effects during craving and drug seeking under specific conditions where drug taking is perceived as risky and/or where there is conflict between drug taking and more adaptive goals.

Examining the role of the insular cortex in addiction-relevant behaviours

This work demonstrates involvement of the RAIC, but not CGIC, in cognitive aspects of addictive disorders, such as gambling-relevant behaviours, and therapeutics using electrical modulation to target the CGIC may be preferable for substance dependence, with limited cognitive side effects.

Translational strategies for therapeutic development in nicotine addiction: Rethinking the conventional bench to bedside approach

HIV-Tat Protein mediation of NeuroAIDS central nervous system pathology and behavioral deficits

OF DISSERTATION Submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Psychology in the Graduate School of Arts and Sciences of Northeastern University, June,

Reward and adversity processing circuits, their competition and interactions with dopamine and serotonin signaling

D dopamine attenuates the output of the adversity processing circuit, thus decreasing inhibitory avoidance and self-control, while serotonin attenuates dACC, AI, clOFC, D1 loop of VS, LHb, amygdala and pain pathway.

What does addiction medicine expect from neuroscience? From genes and neurons to treatment responses.

  • B. Le Foll
  • Biology, Medicine
    Progress in brain research
  • 2016

Nicotine Addiction: Mechanisms and Consequences

This work aims to provide a systematic review and meta-analysis of the literature on canine coronavirus infection and its role in the pathophysiology of schizophrenia and its treatment by emphasizing the importance of cleanliness and minimizing the number of infections.



Anhedonia after a selective bilateral lesion of the globus pallidus.

Comprehensive neuropsychological tests revealed intact cognitive functions, including attention, working memory, and executive function, and an indicated absence of a frontal-subcortical syndrome in a 34-year-old man who came to the authors' outpatient clinic for treatment of a major depressive episode.

Brain metabolic changes during cigarette craving.

Brain regions associated with arousal, compulsive repetitive behaviors, sensory integration, and episodic memory are activated during exposure to cigarette-related cues and cigarette craving, similar to findings with other addictive substances.

Neuropsychiatric effects of insular stroke.

Subjective feelings of impaired energy or drive after right insular damage may result from disconnection between the insula and the frontal lobe or the anterior cingulate cortex, structures that have been associated with willed action and motor behavior.

The role of insula in language: an unsettled question

In this paper some of Benson's ideas about the role of the insula in language are developed. It is proposed that the insula is involved in two di erent aspects of language. On one hand, the insula

Neural Systems and Cue-Induced Cocaine Craving

Neglect after right insular cortex infarction.

The right insular cortex seems to have a role in awareness of external stimuli, and infarction in this area may lead to neglect in multisensory modalities.

Stereotactic neurosurgical treatment of addiction: minimizing the chances of another 'great and desperate cure'.

The addictions field will need to speak with a united voice to ensure that neurosurgical treatment of addiction is not introduced into developed countries by enthusiastic private practitioners without formal evaluation, as purported 'cures' for heroin addiction all too often are.

Neuroanatomic correlates of stroke-related myocardial injury

Brain regions that were a priori associated with cTnT elevation included the right posterior, superior, and medial insula and the right inferior parietal lobule, indicative of myocardial injury.

Medication screening for smoking cessation: a proposal for new methodologies

The clinical validity of short-term screening studies may improve if these studies simulate some clinical trial procedures within practical limitations, and other research aimed specifically at identifying the mechanisms of therapeutic action of a medication may also profit from using this approach.