Insufficient endogenous redox buffer capacity may underlie neuronal vulnerability to cerebral ischemia and reperfusion

  title={Insufficient endogenous redox buffer capacity may underlie neuronal vulnerability to cerebral ischemia and reperfusion},
  author={P. R{\"o}hnert and U. H. Schr{\"o}der and I. Ziabreva and M. T{\"a}ger and K. Reymann and F. Striggow},
  journal={Journal of Neuroscience Research},
Reactive oxygen species (ROS) are key players in ischemia‐induced neurodegeneration. We investigated whether hippocampal neurons may lack sufficient redox‐buffering capacity to protect against ROS attacks. Using organotypic hippocampal slice cultures (OHSCs) transiently exposed to oxygen and glucose deprivation (OGD) and gerbils suffering from a two‐vessel occlusion (2VO) as complementary ex vivo and in vivo models, we have elucidated whether the intrinsic redox systems interfere with ischemia… Expand
12 Citations
Motor Cortex and Hippocampus Display Decreased Heme Oxygenase Activity 2 Weeks After Ventricular Fibrillation Cardiac Arrest in Rats
Total flavonoid of Litsea coreana leve exerts anti-oxidative effects and alleviates focal cerebral ischemia/reperfusion injury
  • 9
  • PDF
Protective effects of tetramethylpyrazine analogue Z‐11 on cerebral ischemia reperfusion injury
  • 7
Ambroxol for the treatment of fibromyalgia: science or fiction?
  • 8
  • PDF
Successful treatment of complex regional pain syndrome with topical ambroxol: a case series.
  • 1
  • PDF
Perturbing Gangliosides In-vitro Using Ambroxol as a Treatment for Neurodegeneration
  • Highly Influenced


Absence of glutathione peroxidase‐1 exacerbates cerebral ischemia‐reperfusion injury by reducing post‐ischemic microvascular perfusion
  • 61
  • Highly Influential
Calcium, mitochondria and oxidative stress in neuronal pathology
  • 210
Role of oxidants in ischemic brain damage.
  • 997
Ischemia-reperfusion injury of retinal endothelium by cyclooxygenase- and xanthine oxidase-derived superoxide.
  • 52
Glutamate, calcium, and free radicals as mediators of ischemic brain damage.
  • 207
Dynamics of intracellular calcium and free radical production during ischemia in pyramidal neurons.
  • 89
The protease thrombin is an endogenous mediator of hippocampal neuroprotection against ischemia at low concentrations but causes degeneration at high concentrations.
  • 271
  • PDF
Antioxidants and free radical scavengers for the treatment of stroke, traumatic brain injury and aging.
  • 322
  • PDF
Glutamate induces the production of reactive oxygen species in cultured forebrain neurons following NMDA receptor activation
  • I. Reynolds, T. Hastings
  • Biology, Chemistry
  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1995
  • 720
  • PDF