Insufficient endogenous redox buffer capacity may underlie neuronal vulnerability to cerebral ischemia and reperfusion

@article{Rhnert2012InsufficientER,
  title={Insufficient endogenous redox buffer capacity may underlie neuronal vulnerability to cerebral ischemia and reperfusion},
  author={P. R{\"o}hnert and U. H. Schr{\"o}der and I. Ziabreva and M. T{\"a}ger and K. Reymann and F. Striggow},
  journal={Journal of Neuroscience Research},
  year={2012},
  volume={90}
}
Reactive oxygen species (ROS) are key players in ischemia‐induced neurodegeneration. We investigated whether hippocampal neurons may lack sufficient redox‐buffering capacity to protect against ROS attacks. Using organotypic hippocampal slice cultures (OHSCs) transiently exposed to oxygen and glucose deprivation (OGD) and gerbils suffering from a two‐vessel occlusion (2VO) as complementary ex vivo and in vivo models, we have elucidated whether the intrinsic redox systems interfere with ischemia… Expand
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