Insufficient autophagy promotes bronchial epithelial cell senescence in chronic obstructive pulmonary disease

@inproceedings{Fujii2012InsufficientAP,
  title={Insufficient autophagy promotes bronchial epithelial cell senescence in chronic obstructive pulmonary disease},
  author={Satoko Fujii and Hiromichi Hara and Jun Araya and Naoki Takasaka and Jun ichi Kojima and Saburo Ito and Shunsuke Minagawa and Yoko Yumino and Takeo Ishikawa and Takanori Numata and Makoto Kawaishi and Jun Hirano and Makoto Odaka and Toshiaki Morikawa and Stephen L Nishimura and Katsutoshi Nakayama and Kazuyoshi Kuwano},
  booktitle={Oncoimmunology},
  year={2012}
}
Tobacco smoke-induced accelerated cell senescence has been implicated in the pathogenesis of chronic obstructive pulmonary disease (COPD). Cell senescence is accompanied by the accumulation of damaged cellular components suggesting that in COPD, inhibition of autophagy may contribute to cell senescence. Here we look at whether autophagy contributes to cigarette smoke extract (CSE) - induced cell senescence of primary human bronchial epithelial cells (HBEC), and further evaluate p62 and… CONTINUE READING