Insufficient androgen and FSH signaling may be responsible for the azoospermia of the infantile primate testes despite exposure to an adult-like hormonal milieu.

@article{Majumdar2012InsufficientAA,
  title={Insufficient androgen and FSH signaling may be responsible for the azoospermia of the infantile primate testes despite exposure to an adult-like hormonal milieu.},
  author={Subeer S Majumdar and Kanchan Sarda and Indrashis Bhattacharya and Tony M. Plant},
  journal={Human reproduction},
  year={2012},
  volume={27 8},
  pages={2515-25}
}
BACKGROUND In humans, as well as in other higher primates, the infantile testis is exposed to an adult-like hormonal milieu, but spermatogenesis is not initiated at this stage of primate development. In the present study, we examined the molecular basis of this intriguing infertile state of the primate testis. METHODS The integrity of androgen receptor (AR) and FSH receptor (FSHR) signaling pathways in primary cultures of Sertoli cells (Scs) harvested from azoospermic infant and spermatogenic… CONTINUE READING