Insufficient activation of autophagy allows cellular damage to accumulate in critically ill patients.

@article{Vanhorebeek2011InsufficientAO,
  title={Insufficient activation of autophagy allows cellular damage to accumulate in critically ill patients.},
  author={Ilse Vanhorebeek and Jan Gunst and Sarah Derde and Inge Derese and Magaly Boussemaere and Fabian G{\"u}iza and Wim Martinet and Jean-Pierre Timmermans and Andr{\'e} D'Hoore and Pieter Jozef Wouters and Greet Van den Berghe},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2011},
  volume={96 4},
  pages={
          E633-45
        }
}
CONTEXT Responses to critical illness, such as excessive inflammation and hyperglycemia, may trigger detrimental chain reactions that damage cellular proteins and organelles. Such responses to illness contribute to the risk of (nonresolving) multiple organ dysfunction and adverse outcome. OBJECTIVE We studied autophagy as a bulk degradation pathway able to remove toxic protein aggregates and damaged organelles and how these are affected by preventing hyperglycemia with insulin during critical… CONTINUE READING
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