Instrument for Real-Time Digital Nucleic Acid Amplification on Custom Microfluidic Devices


Nucleic acid amplification tests that are coupled with a digital readout enable the absolute quantification of single molecules, even at ultralow concentrations. Digital methods are robust, versatile and compatible with many amplification chemistries including isothermal amplification, making them particularly invaluable to assays that require sensitive… (More)
DOI: 10.1371/journal.pone.0163060