Instability of the CAG repeat in immortalized fibroblast cell cultures from Huntington's disease transgenic mice.

Abstract

Huntington's Disease transgenic mice were used for an exploration into the stability of a trinucleotide repeat. The brain shows heterogeneous somatic instability that increases quantitatively with age. To test somatic CAG-repeat alterations during long-term culture, DNA was extracted from transgenic tissue, primary fibroblasts, and SV40-immortalized… (More)

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