Corpus ID: 8872283

Instability of dicentric plasmids in yeast (spindle-mediated breakage/heterogeneous plasmid deletions/RAD52 repair/Saccharomyces cerevisiae)

@inproceedings{Mann2016InstabilityOD,
  title={Instability of dicentric plasmids in yeast (spindle-mediated breakage/heterogeneous plasmid deletions/RAD52 repair/Saccharomyces cerevisiae)},
  author={C. Mann and R. Davis},
  year={2016}
}
Dicentric plasmids containing either two copies of centromere 4 or one copy of centromere 4 and one copy of cen- tromere 3 in the yeast plasmid vector YRp17 were constructed in vitro and introduced into yeast cells by DNA transformation. The resulting colonies were heterogeneous for a mixed population of rearranged plasmids. The rearrangements always involved dele- tion of one or both centromere sequences originally present on the plasmid. Heterogeneity was due to the continued production of… Expand

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