Instability of Helios-deficient Tregs is associated with conversion to a T-effector phenotype and enhanced antitumor immunity.

@article{Nakagawa2016InstabilityOH,
  title={Instability of Helios-deficient Tregs is associated with conversion to a T-effector phenotype and enhanced antitumor immunity.},
  author={Hidetoshi Nakagawa and Jessica Margaret Sido and Edwin E. Reyes and Valerie Kiers and Harvey Cantor and H A Kim},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2016},
  volume={113 22},
  pages={6248-53}
}
Expression of the transcription factor Helios by Tregs ensures stable expression of a suppressive and anergic phenotype in the face of intense inflammatory responses, whereas Helios-deficient Tregs display diminished lineage stability, reduced FoxP3 expression, and production of proinflammatory cytokines. Here we report that selective Helios deficiency within CD4 Tregs leads to enhanced antitumor immunity through induction of an unstable phenotype and conversion of intratumoral Tregs into T… CONTINUE READING
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