Instability of Foxp3 expression limits the ability of induced regulatory T cells to mitigate graft versus host disease.

@article{Beres2011InstabilityOF,
  title={Instability of Foxp3 expression limits the ability of induced regulatory T cells to mitigate graft versus host disease.},
  author={Amy J. Beres and Richard Komorowski and Masahiko Mihara and William R. Drobyski},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2011},
  volume={17 12},
  pages={3969-83}
}
PURPOSE Graft versus host disease (GVHD) is the major complication of allogeneic bone marrow transplantation (BMT) and limits the therapeutic efficacy of this modality. Although the role of natural T-regulatory cells (nTreg) in attenuating GVHD has been extensively examined, the ability of induced T-regulatory cells (iTreg) to mitigate GVHD is unknown. The… CONTINUE READING