Instability of CAG-trinucleotide repeats in chronic lymphocytic leukemia.

  title={Instability of CAG-trinucleotide repeats in chronic lymphocytic leukemia.},
  author={Kellie A. Benzow and Michael Duane Koob and Alison Condie and Daniel Catovsky and Estella Matutes and Martin R Yuille and Richard S. Houlston},
  journal={Leukemia & lymphoma},
  volume={43 10},
Anticipation--earlier onset and more severe disease in the offspring generation--is a well documented feature of familial chronic lymphocytic leukaemia (CLL). In a number of Mendelian diseases, anticipation is caused by expansion of contiguous triplets of nucleotides. The severity of disease expression and penetrance is related to the extent of the triplet expansion. To investigate whether repeat nucleotide repeat expansion is a feature of CLL, the repeat expansion detection (RED) technique was… CONTINUE READING

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