Instability of BCR-ABL gene in primary and cultured chronic myeloid leukemia stem cells.

@article{Jiang2007InstabilityOB,
  title={Instability of BCR-ABL gene in primary and cultured chronic myeloid leukemia stem cells.},
  author={Xiaoyan Jiang and Kyi Min Saw and A. H. C. Eaves and Connie G Eaves},
  journal={Journal of the National Cancer Institute},
  year={2007},
  volume={99 9},
  pages={680-93}
}
BACKGROUND Imatinib mesylate treatment causes remissions in a majority of patients with chronic myeloid leukemia (CML), but relapses are an increasing problem. We hypothesized that imatinib-resistant leukemic cells emerge from CML stem cells that acquire BCR-ABL gene mutations even before exposure to BCR-ABL-targeted agents such as imatinib. METHODS Lineage-negative (i.e., immature) CD34+ CD38- CML stem cell-enriched populations were isolated from five patients with chronic phase CML samples… CONTINUE READING
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