Instabilities in the transient response of muscle.

  title={Instabilities in the transient response of muscle.},
  author={Andrej Vilfan and Thomas Duke},
  journal={Biophysical journal},
  volume={85 2},
We investigate the isometric transient response of muscle using a quantitative stochastic model of the actomyosin cycle based on the swinging lever-arm hypothesis. We first consider a single pair of filaments, and show that when values of parameters such as the lever-arm displacement and the cross-bridge elasticity are chosen to provide effective energy transduction, the T(2) curve (the tension recovered immediately after a step displacement) displays a region of negative slope. If filament… CONTINUE READING
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The heat of shortening and dynamic constants of muscle

  • A. V. Hill
  • Am . J . Physiol
  • 1939
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