Insomnia causes, consequences, and therapeutics: An overview

  title={Insomnia causes, consequences, and therapeutics: An overview},
  author={Christopher L. Drake and Timothy Roehrs and Thomas Roth},
  journal={Depression and Anxiety},
There is growing interest in insomnia both from the perspective of recent advances in clinical management as well as research aimed at elucidating its pathophysiology. This theoretical overview of insomnia describes the negative impact, etiological considerations, and pharmacological and behavioral treatments for the disorder, with an emphasis on areas receiving increased research attention. Insomnia, the most prevalent sleep disorder, affects 10–15% of the general population. In population… 

Therapeutic effectiveness and patient acceptance of a vestibular nerve activation intervention in chronic insomnia

There is an increasing need for an alternative treatment for insomnia symptoms, and one promising approach to managing chronic insomnia is non-invasive mechanical vestibular nerve stimulation, which has been demonstrated to affect sleep.

Drugs for insomnia

  • N. Zisapel
  • Psychology, Medicine
    Expert opinion on emerging drugs
  • 2012
This review summarizes published data on the current and emerging insomnia drug classes, rationale for development and associated risks/benefits, and late-stage pipeline orexin OX1/OX2 and serotonin 5HT2A receptor antagonists may hold the potential to address several unmet needs in insomnia pharmacotherapy.

Effects of Melatonin-Rich Milk on Mild Insomnia Symptoms

Earlier detection and intervention for patients with mild insomnia symptoms is necessary, considering the psychiatric and physical ramifications of chronic insomnia, according to the insomnia disorder criteria of DSM-5.

The epidemiology and diagnosis of insomnia.

  • K. Doghramji
  • Psychology, Medicine
    The American journal of managed care
  • 2006
It is shown that abnormal sleep patterns predict lower life expectancy, and that people with insomnia are more likely to develop affective disorders, substance abuse, and other adverse health outcomes.

Yoga for the Treatment of Insomnia among Cancer Patients: Evidence, Mechanisms of Action, and Clinical Recommendations.

Yoga is a well-tolerated mode of exercise with promising evidence for its efficacy in improving insomnia symptoms among cancer patients, and clinical recommendations for prescribing yoga for the treatment of insomnia in this population are provided.

The Effectiveness of Melatonin for Insomnia in Older Adults: A Systematic Review

Although melatonin may be a safe alternative to standard hypnotic therapy, its use will be limited until more information is available regarding appropriate patient selection and dosing, especially when effective therapies exist.

Repercusiones médicas, sociales y económicas del insomnio

The aim is to synthesize the estimations of insomnia prevalence, its different forms of expression, and explore its impact on people’s health, labor productivity and the consumption of health resources, as well to review the therapeutic choices that have proved to be efficient for the treatment.

Insomnia: pathophysiology and implications for treatment.




Nonpharmacological interventions for insomnia: a meta-analysis of treatment efficacy.

Stimulus control and sleep restriction were the most effective single therapy procedures, whereas sleep hygiene education was not effective when used alone.

Medical and socio-professional impact of insomnia.

The study showed that insomnia has socio-professional consequences and is correlated with lower medical status.

Public health and insomnia: economic impact.

There seems to be a lack of understanding between practitioners and patients on the topic of insomnia, which makes it harder for practitioners to define whether the sleep impairment suffered by their patient is the cause for other symptoms or the consequence of an underlying disease.

Nonpharmacologic Treatment of Chronic Insomnia

The findings indicate that nonpharmacological therapies produce reliable and durable changes in several sleep parameters of chronic insomnia sufferers and there is no clear evidence that improved sleep leads to meaningful changes in daytime well-being or performance.

Use of sleep hygiene in the treatment of insomnia.

A review of SH, how this concept has been applied and often modified over the past 24 years, and how it relates to the modern sleep disorder nosology, particularly Inadequate Sleep Hygiene is presented.

A psychiatric perspective on insomnia.

  • W. McCall
  • Psychology, Medicine
    The Journal of clinical psychiatry
  • 2001
Benzodiazepines and nonbenzodiazepine benzidiazepine receptor agonists (BzRAs) have the best evidence for efficacy as hypnotics, although sedating antidepressants are popularly prescribed.

Insomnia: symptom or diagnosis?

  • A. Harvey
  • Psychology, Medicine
    Clinical psychology review
  • 2001

A behavioral perspective on insomnia treatment.

Place of chronic insomnia in the course of depressive and anxiety disorders.

Non-pharmacological management of primary and secondary insomnia among older people: review of assessment tools and treatments.

It is shown that non-pharmacological treatments for primary and secondary insomnia are feasible and effective alternatives to the use of benzodiazepines, and that family physicians should consider these when managing older patients with insomnia.