Insomnia Caused by Serotonin Depletion is Due to Hypothermia.

  title={Insomnia Caused by Serotonin Depletion is Due to Hypothermia.},
  author={Nicholas M F Murray and Gordon F. Buchanan and George B Richerson},
  volume={38 12},
STUDY OBJECTIVE Serotonin (5-hydroxytryptamine, 5-HT) neurons are now thought to promote wakefulness. Early experiments using the tryptophan hydroxylase inhibitor para-chlorophenylalanine (PCPA) had led to the opposite conclusion, that 5-HT causes sleep, but those studies were subsequently contradicted by electrophysiological and behavioral data. Here we tested the hypothesis that the difference in conclusions was due to failure of early PCPA experiments to control for the recently recognized… CONTINUE READING
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