Insoluble DISC1–Boymaw fusion proteins generated by DISC1 translocation

@article{Zhou2010InsolubleDF,
  title={Insoluble DISC1–Boymaw fusion proteins generated by DISC1 translocation},
  author={Xianjin Zhou and Qiang Chen and Katie Schaukowitch and John Kelsoe and Mark A. Geyer},
  journal={Molecular Psychiatry},
  year={2010},
  volume={15},
  pages={670-672}
}
Schizophrenia is a common disease in the general population with 1% prevalence and has a strong genetic component. Although many candidate susceptibility genes have been suggested to carry modest risk for schizophrenia in human genetic studies, no functional mutations have been identified and replication studies have been inconsistent. In contrast, Disrupted-in-schizophrenia (DISC1) was identified as a balanced chromosome translocation on chromosome 1q42 in a large Scottish schizophrenia family… CONTINUE READING

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Boymaw, overexpressed in brains with major psychiatric disorders, may encode a small protein to inhibit mitochondrial function and protein translation.

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  • 2015
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